Steelers 2010 Schedule
| WEEK | DATE | OPPONENT | TIME (ET) | Location | Result |
| Pre | Sat, Aug 14th, 2010 | Detroit | 07:30 PM | Heinz Field | W (23 - 7) |
| Pre | Sat, Aug 21st, 2010 | at NY_Giants | 07:00 PM | Giants Stadium | W (24 - 17) |
| Pre | Sun, Aug 29th, 2010 | at Denver | 08:00 PM | Invesco Field at Mile High | L (34 - 17) |
| Pre | Thu, Sep 2nd, 2010 | Carolina | 07:30 PM | Heinz Field | W (19 - 3) |
| 1 | Sun, Sep 12th, 2010 | Atlanta | 01:00 PM | Heinz Field | W (15 - 9) |
| 2 | Sun, Sep 19th, 2010 | at Tennessee | 01:00 PM | LP Field | W (19 - 11) |
| 3 | Sun, Sep 26th, 2010 | at Tampa_Bay | 01:00 PM | Raymond James Stadium | W (38 - 13) |
| 4 | Sun, Oct 3rd, 2010 | Baltimore | 01:00 PM | Heinz Field | L (17 - 14) |
| 5 | Bye | ||||
| 6 | Sun, Oct 17th, 2010 | Cleveland | 01:00 PM | Heinz Field | W (28 - 10) |
| 7 | Sun, Oct 24th, 2010 | at Miami | 01:00 PM | Sun Life Stadium | W (23 - 22) |
| 8 | Sun, Oct 31st, 2010 | at New_Orleans | 08:20 PM | Louisiana Superdome | L (20 - 10) |
| 9 | Mon, Nov 8th, 2010 | at Cincinnati | 08:30 PM | Paul Brown Stadium | W (27 - 21) |
| 10 | Sun, Nov 14th, 2010 | New_England | 08:20 PM | Heinz Field | L (39 - 26) |
| 11 | Sun, Nov 21st, 2010 | Oakland | 01:00 PM | Heinz Field | W (35 - 3) |
| 12 | Sun, Nov 28th, 2010 | at Buffalo | 01:00 PM | Ralph Wilson Stadium | W (19 - 16) |
| 13 | Sun, Dec 5th, 2010 | at Baltimore | 08:20 PM | M&T Bank Stadium | W (13 - 10) |
| 14 | Sun, Dec 12th, 2010 | Cincinnati | 01:00 PM | Heinz Field | W (23 - 7) |
| 15 | Sun, Dec 19th, 2010 | NY_Jets | 04:15 PM | Heinz Field | |
| 16 | Thu, Dec 23rd, 2010 | Carolina | 08:20 PM | Heinz Field | |
| 17 | Sun, Jan 2nd, 2011 | at Cleveland | 01:00 PM | Cleveland Browns Stadium | |